Camptothecin (Mappia foetida)

Camptothecin (Mappia foetida)Camptothecin is an alkaloid compound used as an anti cancer agent. It is a topoisomerase I inhibitor in DNA synthesis. Camptothecin has been shown to bind and stabilize a topoisomerase I DNA complex in vitro, preventing the enzyme from reannealing DNA strands. This inhibition specifically effects the S phase of cell development and ultimately results in apoptosis due to damaged DNA. Camptothecin is found in Mappia foetida (Nothapodytes foetida), a

making it useful for long-term studies

Applications: Antibiotic resistance studies

horizontal gene transfer

the bla gene

PubChem CID: 2737635

4-Nitrophenyl-α-D- glucopyranoside is also used for the detection of glucansucrases and for yeast alpha-D-glucosidase and for crystal structure studies of the complexes of concanavalin A

Fluorogenic substrate soluble in DMSO and other organic solvents

Aspergillus

DDM also allows the protein to be reformed following denaturation

and biochemical experiments involving bacterial growth suppression

How It Works: D-Luciferin serves as the natural substrate for firefly luciferase (FLuc)

da Silva Mendes